EndNote 2025 was released at the end of April, and, like so many tools nowadays, it comes with a new artificial intelligence tool (it seems AI is everywhere, for better or worse).
I managed to install EndNote 2025 a few weeks ago, and have had some time to play with the system.
As you can see, the interface isn't too different from EndNote 21. Though the appearance has been tweaked a bit, it still has a lot of the same features. For a full list of EndNote 2025's new features, you can check out Clarivate's site (I particularly enjoy the Web of Science citing articles feature, which shows you which articles in Web of Science have cited your reference!).
One key difference is the introduction of its new AI powered summarizing tool for PDFs (i.e., key takeaway tool). This large language model (LLM) tool scans the full text of attached PDFs and generates summaries of their content. According to Clarivate, "Neither your input nor the licensed content are stored by the large language model or used for any other purpose than the immediate interaction session. Clarivate does not use your data to directly or indirectly train LLMs."
The tool is only capable of generating summaries for machine readable PDFs (specifically those with OCR optimization), and may sometimes have trouble interpreting PDFs with unexpected formatting quirks.

In cases where a PDF isn't machine readable, or where the formatting can't be interpreted by the tool, the AI will output summaries based on the abstract field of a reference. This can be quite fun to play with, as evinced in the below screenshot.

While EndNote 2025's AI key takeaway tool can only generate basic summaries at this time, it sounds like more AI features are in the works, so stay tuned!