This article on Slate came up on one of my feeds again recently ...
Back when I was a student runner for the ILL Department at an earlier rendition of Ebling Library at UW-Madison, we'd often get requests for some of the early articles about Phineas Gage from the 1800s, He was a railway worker who had an iron spike accidentally blasted through his head, and survived! These articles were in the closed stacks in Micaela's historical journals section and fragile. The articles were requested so often, that we kept copies in the ILL Department so we would not have to disturb the originals in the history section and risk further degradation.
It was a fascinating case study. I remember the article saying that when he was recovering from the accident, mushrooms started to grow out of his wound. His physician removed the mushrooms, and cleaned the wound with alcohol, and they didn't grow back ... Phineas made a complete recovery -- well, as complete as was possible. People love to talk about his personality change after the accident, but there's some debate about that ...
There are multiple documentaries and articles about this famous patient, if you'd like to learn more. Here are a few:
What if Part of your Brain was Missing. NOVA.
How Phineas Gage's Freak Accident Changed Brain Science. To the Best of Our Knowledge.Schleim S. Neuroscience Education Begins With Good Science: Communication About Phineas Gage (1823-1860), One of Neurology's Most-Famous Patients, in Scientific Articles. Front Hum Neurosci. 2022 Apr 28;16:734174. doi: 10.3389/fnhum.2022.734174. PMID: 35572004; PMCID: PMC9096075. Link to article.
Why Brain Scientists Are Still Obsessed With The Curious Case Of Phineas Gage - NPR (2017)